BootOneRefFreeEwasModel

<p>model object of class RefFreeEwasModel (generated with smallOutput=FALSE).</p>

<p>Bootstrap generation procedure for reference-free method for conducting EWAS while deconvoluting DNA methylation arising as mixtures of cell types.</p>

deconvolution

DNA methylation

EWAS

surrogate variable

cell mixture


Reference-free method for conducting EWAS while deconvoluting DNA methylation
arising as mixtures of cell types.  The older method
(Houseman et al., 2014,<doi:10.1093/bioinformatics/btu029>) is similar to
surrogate variable analysis (SVA and ISVA), except that it makes additional use
of a biological mixture assumption.
The newer method (Houseman et al., 2016, <doi:10.1186/s12859-016-1140-4>) is similar
to non-negative matrix factorization, with additional constraints
and additional utilities.

E. Houseman

RefFreeEWAS

EWAS using Reference-Free DNA Methylation Mixture Deconvolution

BootOneRefFreeEwasModel function

One Bootstrap sample for Reference-Free EWAS Model — BootOneRefFreeEwasModel

One Bootstrap sample for Reference-Free EWAS Model

BootOneRefFreeEwasModel: One Bootstrap sample for Reference-Free EWAS Model

Description

Usage

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Value

Details

References

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