nlme (version 3.1-68.1)

Quinidine: Quinidine Kinetics

Description

The Quinidine data frame has 1471 rows and 14 columns.

source

Pinheiro, J. C. and Bates, D. M. (2000), Mixed-Effects Models in S and S-PLUS, Springer, New York. (Appendix A.25)

Davidian, M. and Giltinan, D. M. (1995), Nonlinear Models for Repeated Measurement Data, Chapman and Hall, London.

Verme, C. N., Ludden, T. M., Clementi, W. A. and Harris, S. C. (1992), Pharmacokinetics of quinidine in male patients: A population analysis, Clinical Pharmacokinetics, 22, 468-480.

Details

Verme et al. (1992) analyze routine clinical data on patients receiving the drug quinidine as a treatment for cardiac arrythmia (atrial fibrillation of ventricular arrythmias). All patients were receiving oral quinidine doses. At irregular intervals blood samples were drawn and serum concentrations of quinidine were determined. These data are analyzed in several publications, including Davidian and Giltinan (1995, section 9.3).