replicateBE (version 1.1.3)

TRTR.RTRT.TRRT.RTTR: Reference Dataset for TRTR|RTRT|TRRT|RTTR Designs

Description

Dataset from the public domain to be evaluated by method.A() and/or method.B().

Format

• Reference Dataset 23 22 subjects. Unbalanced (four subjects in sequence RTRT and six in each of the other three) and complete. Two outliers (subjects 8 and 17) in sequence TRTR. A data frame with 88 observations on the following 5 variables:

  rds23

  subject	a factor with 22 levels: 1, 2, …, 27
  period	a factor with 4 levels: 1, 2, 3, 4
  sequence	a factor with 4 levels: TRTR, RTRT, TRRT, RTTR
  treatment	a factor with 2 levels: T, R

Details

Dataset

N

(%)

Evaluation

References

U.S. Food and Drug Administration, Center for Drug Evaluation and Research. Bioequivalence Studies. Rockville, 1997. bioequivalence study files (archived 2017-07-23)

Examples

# NOT RUN {
str(rds23)
row <- c(25:28, 5:8, 9:12, 1:4)
rds23[row, ]
summary(rds23[2:5])
# }