empPvalues:
Estimate empirical p-values for $Chi^2$ protein correlations.
Description
Andersen et al. (2003) used a fixed $Chi^2$ threshold of 0.05 to
identify organelle-specific candidates. This function computes
empirical p-values by permutation the markers relative intensities and
computed null $Chi^2$ values.
Usage
empPvalues(marker, corMatrix, n = 100, ...)
Arguments
marker
A numerics with markers relative intensities.
corMatrix
A matrix of nrow(corMatrix) protein relative
intensities to be compares against the marker.
n
The number of iterations.
...
Additional parameters to be passed to chi2.
Value
A numeric of length nrow(corMatrix).
References
Andersen, J. S., Wilkinson, C. J., Mayor, T., Mortensen, P. et al.,
Proteomic characterization of the human centrosome by protein
correlation profiling. Nature 2003, 426, 570 - 574.