Dcov: miRNA target prediction with the Distance correlation method
Description
Calculate the Distance correlation of each pair of miRNA-mRNA,and return a matrix of correlation coefficients with columns are miRNAs and rows are mRNAs.
Usage
Dcov(datacsv, cause, effect, targetbinding = NA)
Arguments
datacsv
the input dataset in csv format
cause
the column range that specifies the causes (miRNAs), e.g. 1:35
effect
the column range that specifies the effects (mRNAs), e.g. 36:2000
targetbinding
the putative target, e.g. "TargetScan.csv". If targetbinding is not specified, only expression data is used.
If targetbinding is specified, the prediction results using expression data with be intersected with the interactions in the target binding file.
Value
A matrix that includes the Distance correlation values. Columns are miRNAs, rows are mRNAs.
References
Szekely, G., Rizzo, M. and Bakirov, N. (2007) Measuring and testing independence by correlation of distances. Ann. Stat., 35, 2769 - 94.