## EXAMPLE 1:
## If a scientist is asked for their best guess for the diagnostic sensitivity
## of a particular test and the answer is 0.90, and if they are also willing
## to assert that they are 80% certain that the sensitivity is greater than
## 0.75, what are the shape1 and shape2 parameters for a beta distribution
## satisfying these constraints?
rval.beta01 <- epi.betabuster(mode = 0.90, conf = 0.80, imsure = "greater than",
x = 0.75, conf.level = 0.95, max.shape1 = 100, step = 0.001)
rval.beta01$shape1; rval.beta01$shape2
## The shape1 and shape2 parameters for the beta distribution that satisfy the
## constraints listed above are 9.875 and 1.986, respectively.
## This beta distribution reflects the probability distribution obtained if
## there were 9 successes, r:
r <- rval.beta01$shape1 - 1; r
## from 10 trials, n:
n <- rval.beta01$shape2 + rval.beta01$shape1 - 2; n
dat.df01 <- data.frame(x = seq(from = 0, to = 1, by = 0.001),
y = dbeta(x = seq(from = 0, to = 1,by = 0.001),
shape1 = rval.beta01$shape1, shape2 = rval.beta01$shape2))
## Density plot of the estimated beta distribution:
if (FALSE) {
library(ggplot2)
ggplot(data = dat.df01, aes(x = x, y = y)) +
theme_bw() +
geom_line() +
scale_x_continuous(name = "Test sensitivity") +
scale_y_continuous(name = "Density")
}
## EXAMPLE 2:
## The most likely value of the specificity of a PCR for coxiellosis in
## small ruminants is 1.00 and we're 97.5% certain that this estimate is
## greater than 0.99. What are the shape1 and shape2 parameters for a beta
## distribution satisfying these constraints?
epi.betabuster(mode = 1.00, conf = 0.975, imsure = "greater than", x = 0.99,
conf.level = 0.95, max.shape1 = 100, step = 0.001)
## The shape1 and shape2 parameters for the beta distribution that satisfy the
## constraints listed above are 100 and 1, respectively. epi.betabuster
## issues a warning that the value of shape1 equals max.shape1. Increase
## max.shape1 to 500:
epi.betabuster(mode = 1.00, conf = 0.975, imsure = "greater than", x = 0.99,
conf.level = 0.95, max.shape1 = 500, step = 0.001)
## The shape1 and shape2 parameters for the beta distribution that satisfy the
## constraints listed above are 367.04 and 1, respectively.
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