qtl (version 1.70)

formLinkageGroups: Partition markers into linkage groups

Description

Use pairwise linkage information between markers (as calculated by est.rf to partition markers into linkage groups.

Usage

formLinkageGroups(cross, max.rf=0.25, min.lod=3, reorgMarkers=FALSE,
                  verbose=FALSE)

Value

If reorgMarkers=FALSE (the default), the output is a data frame with rows corresponding to the markers and with two columns: the initial chromosome assignment and the inferred linkage group. Linkage groups are ordered by the number of markers they contain (from largest to smallest).

If reorgMarkers=TRUE, the output is a cross object, like the input, but with the markers reorganized into the inferred linkage groups. The marker order and marker positions within the linkage groups are arbitrary.

Arguments

cross

An object of class cross. See read.cross for details.

max.rf

Maximum recombination fraction for placing two markers in the same linkage group (see Details).

min.lod

Minimum LOD score for placing two markers in the same linkage group (see Details).

reorgMarkers

If TRUE, the output is a cross object, like the input, but with the markers organized into the inferred linkage groups. If FALSE, the output is a table indicating the initial chromosome assignments and the inferred linkage group partitions.

verbose

If TRUE, display information about the progress of the calculations.

Author

Karl W Broman,

Details

Two markers are placed in the same linkage group if the estimated recombination fraction between them is \(\le\) max.rf and the LOD score (for the test of the rec. frac. = 1/2) is \(\ge\) min.lod. The transitive property (if A is linked to B and B is linked to C then A is linked to C) is used to close the groups.

See Also

est.rf, orderMarkers

Examples

data(listeria)
listeria <- est.rf(listeria)
result <- formLinkageGroups(listeria)
tab <- table(result[,1], result[,2])
apply(tab, 1, function(a) sum(a!=0))
apply(tab, 2, function(a) sum(a!=0))