LW1949 (version 1.1.0)

gamtable1: Fit a smooth GAM to Table 1 of Litchfield and Wilcoxon (1949)

Description

Fit a smooth GAM function to replace looking up values in Table 1 of Litchfield and Wilcoxon (1949).

Usage

gamtable1()

Value

A gamObject that can be used to predict the corrected values (as proportions) from distexpprop5, the distance between the expected values (as proportions) and 0.5

Details

Note that for an expected value of 37 Table 1 gives a corrected value of 9.4, but for an expected value of 63 it gives a corrected value of 90.5. To ensure that both values add to 100, I used corrected values of 9.45 and 90.55. The expected and corrected values from Table 1 are then used to build a GAM model, which is used as input to the correctval function.

References

Litchfield, JT Jr. and F Wilcoxon. 1949. A simplified method of evaluating dose-effect experiments. Journal of Pharmacology and Experimental Therapeutics 96(2):99-113. http://jpet.aspetjournals.org/content/96/2/99.abstract.

Examples

fit <- gamtable1()
summary(fit)
plot(fit)