Compute the modified Haybittle-Peto boundary
mHP.b(mu = c(0, 0), v = c(1, 2), alpha = 0.05, eps = 1/2, side = c("one", "two"))The mean vector
The variance vector, usually proportional to information in calendar time
The significance desired
The fraction of alpha to use
one-sided or two-sided (one or two)
the modified Haybittle-Peto boundary
Compute the modified Haybittle-Peto boundary
Lai, Tze Leung and Lavori, Philip W. and Shih, Mei-Chiung. Sequential Design of Phase II-III Cancer Trials, Statistics in Medicine, Volume 31, issue 18, p.1944-1960, 2012.