Mean segmentation on the genomic signal is performed using the Fpsn function of the jointseg package.
Usage
segmented_signal(SNP.Chr, Kmax)
Arguments
SNP.Chr
SNP/CGH profile matrix for a given chromosome (NA's not allowed). Columns correspond to patients and rows to probes.
Kmax
Maximum number of segments.
Value
Smoothed genomic signal matrix. Rows correspond to probes and columns to patients.
References
Morgane Pierre-Jean, Guillem Rigaill and Pierre Neuvial. Performance evaluation of DNA copy number segmentation methods. Briefings in Bioinformatics (2015) 16 (4): 600-615.