A summarization method to estimate allele-specific copy number signals for Affymetrix SNP microarrays using non-negative matrix factorization (NMF).
Arguments
Installation and updates
This package requires the aroma.affymetrix package.
To install this package, do:
install.packages("ACNE")
To get started
For a one-command pipeline, see the doACNE() method.
For other usages, see the NmfPlm class.
Author
Maria Ortiz, Henrik Bengtsson, Angel Rubio
License
LGPL (>= 2.1)
References
[1] M. Ortiz-Estevez, H. Bengtsson, A. Rubio, ACNE: a summarization method to estimate allele-specific copy numbers for Affymetrix SNP arrays, Bioinformatics, 2010 [PMC2913655].