Learn R Programming
ACNE (version 0.9.1)

WHInit: Initialization of the W and H matrices

Description

Initialization of the W and H matrices.

Usage

WHInit(V, ...)

Value

Returns a list:

W

A Kx2 matrix of initial probe-affinity estimates.

H

A 2xI matrix of initial allele-specific copy-number estimates.

status

An integer specifying the status of the initialization: 0=normal case, 1=only one allele (either AA or BB), or 2=all samples are AB.

Arguments

V

An KxI matrix where I is the number of arrays and K is the number of probes where K should be even (K=2L).

...

Not used.

Details

The allele-specific copy number estimates are estimated using a naive genotyping algorithm. The probe-affinities are estimated using a pseudo inverse.