ANTsR (version 0.7.2.0)

testEanat: Test eigenanatomy in order

Description

This tests each eigenanatomy region in order invisibly to the user and stops when testing stops conserving power. The algorithm returns NA if there is no good testing procedure, given the statistical target. The basic idea is to test the variables that explain the most variance first and continue testing as long as (a) there is no significant relationship yet found or (b) the existing significant relationship remains significant, given the correction for multiple comparisons.

Usage

testEanat(mymdl, myvar, sigthresh = 0.05, method = "BH")

Arguments

mymdl

input model from lm with eigenanatomy on left

myvar

name of variable in model to test

sigthresh

significance threshold, for example 0.05

method

a method for p.adjust

Value

nvecs is output, analogous to nvecs in svd(mat,nu=0,nv=nvecs)

References

Avants BB, Hackman D, LM Betancourt, GM Lawson, H Hurt, MJ Farah #' Relation of Childhood Home Environment to Cortical Thickness in Late Adolescence: Specificity of Experience and Timing, PloS one, 2015

Examples

# NOT RUN {
mat <- matrix(rnorm(300),ncol=3)
n = nrow(mat)
g = factor( c(rep(1,n/2),rep(0,n/2)) )
mydf = data.frame( gen=g, a=rnorm(n))
mymdl<-lm( mat ~ a + g , data=mydf )
nv = testEanat( mymdl, myvar="g1" )
mat[1:(n/2),3] = mat[1:(n/2),3] + 2
mymdl<-lm( mat ~ a + g , data=mydf )
nv = testEanat( mymdl, myvar="g1" )

# }