AssocTests (version 1.0-1)
Genetic Association Studies
Description
Some procedures including EIGENSTRAT (a procedure for detecting and correcting
for population stratification through searching for the eigenvectors in genetic association
studies), PCoC (a procedure for correcting for population stratification through calculating
the principal coordinates and the clustering of the subjects), Tracy-Widom test (a procedure
for detecting the significant eigenvalues of a matrix), distance regression (a procedure for
detecting the association between a distance matrix and some independent variants of interest),
single-marker test (a procedure for identifying the association between the genotype at a
biallelic marker and a trait using the Wald test or the Fisher's exact test), MAX3 (a procedure
for testing for the association between a single nucleotide polymorphism and a binary phenotype
using the maximum value of the three test statistics derived for the recessive, additive, and
dominant models), nonparametric trend test (a procedure for testing for the association between
a genetic variant and a non-normal distributed quantitative trait based on the nonparametric
risk), and nonparametric MAX3 (a procedure for testing for the association between a biallelic
single nucleotide polymorphism and a quantitative trait using the maximum value of the three
nonparametric trend tests derived for the recessive, additive, and dominant models), which are
commonly used in genetic association studies. To cite this package in publications use:
Lin Wang, Wei Zhang, and Qizhai Li. AssocTests: An R Package for Genetic Association Studies.
Journal of Statistical Software. 2020; 94(5): 1-26.