AssotesteR (version 0.1-10)

ASUM: ASUM: Adaptive Sum Statistic

Description

The adaptive Adaptive Sum test has been proposed by Han and Pan (2010) in an attempt to overcome some of the drawbacks of the SUM test, by extending the idea of the adaptive Neyman's test (Fan, 1996). The approach behind the adaptive test is to use the U-statistics of the score test (from logistic regression models) in order to construct a statistic with the first components of the score vector U.

Usage

ASUM(y, X, perm = 100)
  ASUM.Ord(y, X, perm = 100)

Arguments

y

numeric vector with phenotype status: 0=controls, 1=cases. No missing data allowed

X

numeric matrix or data frame with genotype data coded as 0, 1, 2. Missing data is allowed

perm

positive integer indicating the number of permutations (100 by default)

Value

"assoctest", basically a list with the following elements:

asum.stat

asum statistic

perm.pval

permuted p-value

args

descriptive information with number of controls, cases, variants, and permutations

name

name of the statistic

Details

ASUM gives the normal (unordered) test. ASUM.Ord gives the ordered (decreasing) test.

There is no imputation for the missing data. Missing values are simply ignored in the computations.

References

Han F, Pan W (2010) A Data-Adaptive Sum Test for Disease Association with Multiple Common or Rare Variants. Human Heredity, 70: 42-54

Pan W, Shen X (2011) Adaptive Tests for Association of Rare Variants. Genetic Epidemiology, 35: 381-388

See Also

SUM

Examples

  ## Not run: 
# 
#   # number of cases
#   cases = 500
# 
#   # number of controls
#   controls = 500
# 
#   # total (cases + controls)
#   total = cases + controls
# 
#   # phenotype vector
#   phenotype = c(rep(1, cases), rep(0, controls))
# 
#   # genotype matrix with 10 variants (random data)
#   set.seed(123)
#   genotype = matrix(rbinom(total*10, 2, 0.05), nrow=total, ncol=10)
# 
#   # apply ASUM with 500 permutations
#   myasum = ASUM(phenotype, genotype, perm=500)
#   myasum
# 
#   # apply ASUM.Ord with 500 permutations
#   myasumord = ASSU.Ord(phenotype, genotype, perm=500)
#   myasumord
#   ## End(Not run)