getneighborhood_fastcpp

an efficient function to find the neighborhood based on the matrix of position and a pre-defined cutoff

Biotechnology in spatial omics has advanced rapidly over the past few years, enhancing both throughput and resolution. However, existing annotation pipelines in spatial omics predominantly rely on clustering methods, lacking the flexibility to integrate extensive annotated information from single-cell RNA sequencing (scRNA-seq) due to discrepancies in spatial resolutions, species, or modalities. Here we introduce the CAESAR suite, an open-source software package that provides image-based spatial co-embedding of locations and genomic features. It uniquely transfers labels from scRNA-seq reference, enabling the annotation of spatial omics datasets across different technologies, resolutions, species, and modalities, based on the conserved relationship between signature genes and cells/locations at an appropriate level of granularity. Notably, CAESAR enriches location-level pathways, allowing for the detection of gradual biological pathway activation within spatially defined domain types. More details on the methods related to our paper currently under submission. A full reference to the paper will be provided in future versions once the paper is published.

Xiao Zhang

CAESAR.Suite

CAESAR: a Cross-Technology and Cross-Resolution Framework for
Spatial Omics Annotation

Wei Liu

Jin Liu

getneighborhood_fastcpp function

<dl><dt>x</dt>
<dd>is a n-by-2 matrix of position.</dd>
<dt>radius</dt>
<dd>is a threashold of Euclidean distance to decide whether a spot is an neighborhood of another spot. For example, if the Euclidean distance between spot A and B is less than cutoff, then A is taken as the neighbourhood of B.</dd></dl>

Arguments

getneighborhood_fast — getneighborhood_fastcpp

<dl>

<dt>x</dt>
<dd>is a n-by-2 matrix of position.</dd>


<dt>radius</dt>
<dd>is a threashold of Euclidean distance to decide whether a spot is an neighborhood of another spot. For example, if the Euclidean distance between spot A and B is less than cutoff, then A is taken as the neighbourhood of B.</dd>

</dl>

getneighborhood_fastcpp: getneighborhood_fast

Description

Usage

Value

Arguments