COMBIA (version 1.0.6)

applyLoewe: This function calculates Loewe synergy/antagonism and associated BIs

Description

This function calculates Loewe synergy/antagonism and associated BIs

Usage

applyLoewe(rawDataPreProcessed, xConcentration, yConcentration, nBoot)

Arguments

rawDataPreProcessed

Raw preprocessed experimental data

xConcentration

X drug concentrations

yConcentration

Y drug concentrations

nBoot

Number of times to bootstrap

Value

Three lists, first list consisting of Loewe Synergy/Antagonism, lower bound of BI and upper bound of BI. 2nd list consists of global BI for maximum synergy and 3rd list consists of global BI of maximum antagonistic combination.

Examples

# NOT RUN {
dataFile <- system.file("extdata", "rawDataPreProcessed.csv", package="COMBIA")
dataSample <- read.csv(dataFile, header=FALSE )
xConc  <- c(0.00,  0.20,  0.39,  0.78,  1.56,3.12,  6.25, 12.50, 25.00, 50) 
yConc <- c(128,  64,  32,  16,   8,   4,   2,   0)
noOFBoot <- 500 # a large number is recomended
rslt <- applyLoewe(as.matrix(dataSample), xConc, yConc, noOFBoot)
# }