CUtools (version 0.1.0)

Efficacy: Estimate the efficacy of a biomarker

Description

The efficacy of a biomarker is defined by the treatment saved below a cut-off point minus the missclasified events.

Usage

Efficacy(Prob,yt,z)

Value

The returned object contains the Efficacy of the biomarker Prob at a specific z rate of missclasified events

Efficacy

Efficacy of the biomarker Prob at a specific z rate of missclasified events

Arguments

Prob

A vector with the event probability values provided by the biomarker

yt

A vector with the actual event values

z

The misclassification rate at which the effectiveness of the marker will be estimated.

Author

Maria Escorihuela, Luis Mariano Esteban, Gerardo Sanz, Angel Borque

Details

Prob must be a numeric vector with values between 0 and 1, yt a numeric vector with dichotomic values 0/1 and z a numeric value between 0 and 100

Examples

###We generate a marker to serve as an example

Prob<-c(rnorm(10000,0.4,0.1),rnorm(10000,0.5,0.05))
yt<-rep(c(0,1),c(10000,10000))
#We choose a rate of 10% for misclassified events.
Efficacy(Prob=Prob,yt=yt,z=10)