A dataset that contains genotypes simulated by gene drop based on a model of linkage disequilibrium fit to data from a candidate-gene case-control study. Several close relative pairs have been included in the simulated data.
data(Nhlsim)
A list comprised of the following four objects:
[[1]] | snp.data | a snp.matrix object containing genotypes of 208 subjects (108 controls and 100 cases). |
Rows correspond to subjects and columns correspond to SNPs | ||
[[2]] | chromosome | a numeric vector containing the chromosome numbers of the SNPs |
[[3]] | physmap | a numeric vector of physical positions |
[[4]] | csct | a vector of case-control status (1=case, 0=control) |
The dataset contains mostly unrelated individuals, but includes two parent-offspring pairs and three full-siblings pairs to show how the CrypticIBDcheck package can be used to uncover cryptic relatedness.
Schuetz JM, Daley D, Graham J, Berry BR, Gallagher RP, Connors JM, Gascoyne RD, Spinelli JJ, Brooks-Wilson AR (2012). Genetic Variation in Cell Death Genes and Risk of Non-Hodgkin Lymphoma. PLoS ONE, 7(2), e31560. doi:10.1371/journal.pone.0031560.