Traditional phasing programs are limited to diploid organisms. Our method modifies Li and Stephens algorithm with Markov chain Monte Carlo (MCMC) approaches, and builds a generic framework that allows haplotype searches in a multiple infection setting. This package is primarily developed as part of the Pf3k project, which is a global collaboration using the latest sequencing technologies to provide a high-resolution view of natural variation in the malaria parasite Plasmodium falciparum. Parasite DNA are extracted from patient blood sample, which often contains more than one parasite strain, with unknown proportions. This package is used for deconvoluting mixed haplotypes, and reporting the mixture proportions from each sample.
Traditional phasing programs are limited to diploid organisms. Our method modifies Li and Stephens algorithm with Markov chain Monte Carlo (MCMC) approaches, and builds a generic framework that allows haplotype searches in a multiple infection setting. This package is primarily developed as part of #' the Pf3k project, which is a global collaboration using the latest sequencing technologies to provide a high-resolution view of natural variation in the malaria parasite Plasmodium falciparum. Parasite DNA are extracted from patient blood sample, which often contains more than one parasite strain, with unknown proportions. This package is used for deconvoluting mixed haplotypes, #' and reporting the mixture proportions from each sample.
Maintainer: Joe Zhu sha.joe.zhu@gmail.com [copyright holder]
Authors:
Jacob Almagro-Garcia
Gil McVean
Other contributors:
University of Oxford [copyright holder]
Yinghan Liu [contributor]
CodeCogs Zyba Ltd [compiler, copyright holder]
Deepak Bandyopadhyay [compiler, copyright holder]
Lutz Kettner [compiler, copyright holder]
Zhu Sha
Maintainer: Joe Zhu sha.joe.zhu@gmail.com
Useful links: