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DSAIRM (version 0.5.0)

Dynamical Systems Approach to Immune Response Modeling

Description

A collection of 'shiny' apps that allow for the simulation and exploration of various within-host immune response scenarios. The purpose of the package is to help individuals learn about within-host infection and immune response modeling from a dynamical systems perspective. All apps include explanations of the underlying models and instructions on what to do with the models. The development of this package was partially supported by NIH grant U19AI117891.

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Version

Install

install.packages('DSAIRM')

Monthly Downloads

270

Version

0.5.0

License

GPL-3

Issues

0

Pull Requests

0

Stars

34

Forks

15

Maintainer

Andreas Handel

Last Published

January 17th, 2019

Functions in DSAIRM (0.5.0)

generate_plots

A helper function that takes result from the simulators and produces plots
simulate_virusandtx_ode

Simulation of a basic viral infection model with drug treatment
simulate_basicvirus_ode

Basic Virus model - ODE
simulate_basicvirus_stochastic

Stochastic simulation of a compartmental acute virus infection model
simulate_modelcomparison_fit

Fitting 2 simple viral infection models to influenza data
simulate_modelexploration

Simulation to illustrate parameter scan of the basic bacteria model #'
simulate_drugresistance_stochastic

Stochastic simulation of a compartmental acute virus infection model with treatment and drug resistant strain
simulate_confint_fit

Fit a simple viral infection model and compute confidence intervals
simulate_modelvariants_ode

Simulation of a viral infection model with immune response The simulation illustrates different alternative models.
simulate_usanalysis

Simulation to illustrate uncertainty and sensitivity analysis
simulate_virusandir_ode

Simulation of a viral infection model with an immune response
simulate_pkpdmodel_ode

PkPd Virus model
simulate_basicbacteria_discrete

Basic Bacteria model - discrete
DSAIRM

DSAIRM: A package to learn about Dynamical Systems Approaches to Immune Response Modeling
run_model

A function that runs a DSAIRM/DSAIDE app
dsairmmenu

The main menu for the DSAIRM package
simulate_basicbacteria_ode

Basic Bacteria model - ODE
generate_shinyinput

A helper function that takes a model and generates the shiny UI elements for the analyze tab
simulate_basicmodel_fit

Fitting a simple viral infection models to influenza data
generate_documentation

A helper function for the UI part of the Shiny apps
generate_text

A helper function that takes result from the simulators and produces text output