DSS is an R library performing the differential expression analysis for
RNA-seq count data. Compared with other similar packages (DESeq,
edgeR), DSS implements a new dispersion shrinkage method to estimate the
gene-specific biological variance. Extensive simulation results
showed that DSS performs favorabily compared to DESeq and edgeR when
the variation of biological variances is large. DSS only works for two group comparison at this time. We plan to
extend the functionalities and make it work for more general
experimental designs in the near future.