titration

titration,DE,numeric-method

An object of S4 class <code><a rd-options="=DE-class" href="/link/DE?package=DTAT&version=0.3-4&to=%3DDE-class" data-mini-rdoc="=DE-class::DE">DE</a></code>

The number of DLT assessment periods to titrate over.
Should be a positive integer.

periods

May be used to pass <code>verbatim = 'TRUE'</code> to internal
<code>step_time</code> method.

Simulate a &#8216;3+3/PC&#8217; dose-titration trial

Dose Titration Algorithm Tuning (DTAT) is a methodologic framework
allowing dose individualization to be conceived as a continuous
learning process that begins in early-phase clinical trials and
continues throughout drug development, on into clinical practice.
This package includes code that researchers may use to reproduce
or extend key results of the DTAT research programme, plus tools
for trialists to design and simulate a '3+3/PC' dose-finding study.
Please see Norris (2017) <doi:10.12688/f1000research.10624.3> and
Norris (2017) <doi:10.1101/240846>.

David C. Norris

DTAT

Dose Titration Algorithm Tuning

titration function

<dl><dt>x</dt>
<dd>An object of S4 class <code>DE</code></dd>
<dt>periods</dt>
<dd>The number of DLT assessment periods to titrate over.
Should be a positive integer.</dd>
<dt>...</dt>
<dd>May be used to pass <code>verbatim = 'TRUE'</code> to internal
<code>step_time</code> method.</dd></dl>

Arguments

Simulate a &#8216;3+3/PC&#8217; dose-titration trial — titration

<dl>

<dt>x</dt>
<dd>An object of S4 class <code>DE</code></dd>


<dt>periods</dt>
<dd>The number of DLT assessment periods to titrate over.
Should be a positive integer.</dd>


<dt>...</dt>
<dd>May be used to pass <code>verbatim = 'TRUE'</code> to internal
<code>step_time</code> method.</dd>

</dl>

titration: Simulate a ‘3+3/PC’ dose-titration trial

Description

Usage

Arguments

References