DTAT (version 0.3-7)

de.bioRxiv.240846: Simulated ‘3+3/PC’ dose-titration study from bioRxiv paper no. 240846

Description

This is a length-10 list of data frames, summarizing the simulated trial from this paper, at the end of periods 1, 2, ..., 10. This structure reflects an awkward S3 implementation that package DTAT v0.3 reimplemented using S4. This data set is retained to support regression tests.

Format

A length-10 list of data frames, each with the following columns:

id

Participant identifier

period

DLT assessment period, numbered consecutively from 1

dose

Dose level, numbered consecutively starting from 1

dlt

A logical indicator: did this this participant experience a DLT during this period?

Details

A stop.esc attribute is attached to data frames in this list, indicating when escalation stopped during the simulated trial.

References

Norris DC. Precautionary Coherence Unravels Dose Escalation Designs. bioRxiv. December 2017:240846. tools:::Rd_expr_doi("10.1101/240846"). https://www.biorxiv.org/content/10.1101/240846v1

Examples

data(de.bioRxiv.240846)
# Demonstrate that the new S4 3+3/PC implementation reproduces the
# simulated trial from the paper:
set.seed(2017)
CV <- 0.7; mean_mtd <- 1.0
shape <- CV^-2; scale <- mean_mtd/shape
trial <- new("DE", doses=0.25 * 1.4^(0:6),
             MTDi=rgamma(24, shape=shape, scale=scale),
             units="mg")
trial <- titration(trial, periods=10)
stopifnot(all(trial@data == de.bioRxiv.240846[[10]]))
stopifnot(trial@stop_esc == attr(de.bioRxiv.240846[[10]],'stop.esc'))