DTComPair (version 1.2.6)

sesp.exactbinom: Exact Binomial Test for Differences in Sensitivity and Specificity

Description

Performs an exact binomial test for differences in sensitivity and specificity of two binary diagnostic tests in a paired study design.

Usage

sesp.exactbinom(tab) 

Value

A list containing:

sensitivity

A list containing test1 (sensitivity of test 1), test2 (specificity of test 2), diff (the difference in sensitivity, computed as test2 - test1) and the corresponding p.value.

specificity

A list containing test1 (specificity of test 1), test2 (specificity of test 2), diff (the difference in specificity, computed as test2 - test1) and the corresponding p.value.

method

The name of the method used to compare sensitivity and specificity, here “exactbinom”.

Arguments

tab

An object of class tab.paired.

Details

The function performs a standard exact binomial test.

An exact binomial test is recommended when the number of patients with differing results for test 1 and test 2 (discordant pairs) is small, i.e. <20 (Zhou et al., 2011).

References

Zhou, X., Obuchowski, N., and McClish, D. (2011). Statistical Methods in Diagnostic Medicine. Wiley Series in Probability and Statistics. John Wiley & Sons, Hoboken, New Jersey, 2nd edition.

See Also

sesp.mcnemar and tab.paired.

Examples

data(Paired1) # Hypothetical study data
ftable(Paired1)
paired.layout <- tab.paired(d=d, y1=y1, y2=y2, data=Paired1)
paired.layout 
exact.results <- sesp.exactbinom(paired.layout)
str(exact.results)
exact.results
exact.results$sensitivity["p.value"]