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DoseFinding (version 0.5-5)

getGrad: Calculate the gradient for the non-linear part of a DRMod object

Description

Calculate the gradient for the non-linear part of a DRMod object. The gradient is used to calculate variance covariance matrix, confidence intervals and confidence intervals for predictions, based on a linearization of the non-linear model see Seber and Wild (2003) for details. This function is also used to calculate the design criterion for the calcOptDesign function (which depends on the asymptotic covariance matrix).

Usage

getGrad(object, dose, uGrad = NULL)

Arguments

object
A DRMod object
dose
Dose where to evaluate the gradient
uGrad
Function to return the gradient of a user defined model, see Examples of the fitDRModel function.

Value

  • Matrix containing the gradient

References

Seber, G.A.F and Wild, C.F. (2003). Nonlinear Regression, Wiley & Sons

See Also

vcov.DRMod, predict.DRMod, intervals.DRMod,fitDRModel