DynTxRegime (version 3.2)

.newBOWLOptimization: Backward Outcome Weighted Learning With and Without Subsetting of Regime.

Description

Estimates the optimal treatment using outcome weighted learning for a single decision point. Method is not exported.

Usage

.newBOWLOptimization(regime, ...)
# S4 method for formula
.newBOWLOptimization(regime, txInfo, ind, prWgt, response, txVec, data, kernel, 
                     kparam, lambdas, cvFolds, suppress)
# S4 method for list
.newBOWLOptimization(regime, txInfo, ind, prWgt, response, txVec, data, kernel, 
                     kparam, lambdas, cvFolds, suppress)

Arguments

regime

"formula" description of decision rule.

...

Used to pass arguments that are required but the class of which does not determine the method that is selected.

txInfo

Treatment information object.

ind

T/F indicating if optimal treatment has been followed beyond this decision point.

prWgt

Product of probabilities for treatment received beyond this decision point.

response

Sum of rewards including this decision point.

txVec

Recast treatment vector as +/-1.

data

"data.frame" of covariates and treatment histories.

kernel

"character" description of kernel function.

kparam

NULL or "numeric" parameter for kernel function.

lambdas

Tuning parameter(s).

cvFolds

Number of cross-validation folds.

suppress

T/F indicating if print to screens should be executed.

Examples

# NOT RUN {
data(bmiData)

y <- -(bmiData$month12BMI - bmiData$month4BMI) / bmiData$month4BMI * 100
miny <- min(y)
if(miny < 0.0) y <- y - miny

prWgt <- numeric(nrow(bmiData)) + 0.5

regime <- ~ parentBMI + baselineBMI + gender

txVec <- numeric(nrow(bmiData)) - 1L
txVec[bmiData$A2 == "MR"] <- 1L
bmiData$A2 <- as.factor(bmiData$A2)

txInfo <- DynTxRegime:::.newTxInfo(fSet = NULL, txName = "A2", data = bmiData, 
                                   suppress = TRUE, verify = TRUE)

obj <- DynTxRegime:::.newBOWLOptimization(regime = regime,
                                          txInfo = txInfo,
                                          ind = !logical(nrow(bmiData)),
                                          prWgt = prWgt,
                                          response = y,
                                          txVec = txVec,
                                          data = bmiData,
                                          kernel = "linear",
                                          kparam = NULL,
                                          lambdas = 0.1,
                                          cvFolds = 0L,
                                          suppress = TRUE)

is(obj)
cvInfo(obj)
optimObj(obj)
DynTxRegime:::.predictOptimalTx(obj)
DynTxRegime:::.predictOptimalTx(obj,bmiData)
print(obj)
regimeCoef(obj)
show(obj)
summary(obj)


obj <- DynTxRegime:::.newBOWLOptimization(regime = regime,
                                          txInfo = txInfo,
                                          ind = !logical(nrow(bmiData)),
                                          prWgt = prWgt,
                                          response = y,
                                          txVec = txVec,
                                          data = bmiData,
                                          kernel = "linear",
                                          kparam = NULL,
                                          lambdas = c(0.1,0.2,0.3),
                                          cvFolds = 4L,
                                          suppress = TRUE)

is(obj)
cvInfo(obj)
optimObj(obj)
DynTxRegime:::.predictOptimalTx(obj)
DynTxRegime:::.predictOptimalTx(obj,bmiData)
print(obj)
regimeCoef(obj)
show(obj)
summary(obj)

fSet <- function(data){
          subsets = list(list("subset1", c("CD","MR")),
                         list("subset2", c("CD","MR")))
          txOpts <- character(nrow(data))
          txOpts[data$A1 == "CD"] <- "subset1"
          txOpts[data$A1 == "MR"] <- "subset2"

          return(list("subsets" = subsets, "txOpts" = txOpts))
        }

txInfo <- DynTxRegime:::.newTxInfo(fSet = fSet, txName = "A2", data = bmiData, 
                                   suppress = TRUE, verify = TRUE)

obj <- DynTxRegime:::.newBOWLOptimization(regime = list("subset1"=regime,"subset2"=regime),
                                          txInfo = txInfo,
                                          ind = !logical(nrow(bmiData)),
                                          prWgt = prWgt,
                                          response = y,
                                          txVec = txVec,
                                          data = bmiData,
                                          kernel = "linear",
                                          kparam = NULL,
                                          lambdas = 0.1,
                                          cvFolds = 0L,
                                          suppress = TRUE)

is(obj)
cvInfo(obj)
optimObj(obj)
DynTxRegime:::.predictOptimalTx(obj)
DynTxRegime:::.predictOptimalTx(obj,bmiData)
print(obj)
regimeCoef(obj)
show(obj)
summary(obj)

bmiData$A2[bmiData$A1 == "MR"] <- "CD"

fSet <- function(data){
          subsets = list(list("subset1", c("CD","MR")),
                         list("subset2", c("CD")))
          txOpts <- character(nrow(data))
          txOpts[data$A1 == "CD"] <- "subset1"
          txOpts[data$A1 == "MR"] <- "subset2"

          return(list("subsets" = subsets, "txOpts" = txOpts))
        }

prWgt[bmiData$A1 == "MR"] <- 1.0

txInfo <- DynTxRegime:::.newTxInfo(fSet = fSet, txName = "A2", data = bmiData, 
                                   suppress = TRUE, verify = TRUE)

obj <- DynTxRegime:::.newBOWLOptimization(regime = regime,
                                          txInfo = txInfo,
                                          ind = !logical(nrow(bmiData)),
                                          prWgt = prWgt,
                                          response = y,
                                          txVec = txVec,
                                          data = bmiData,
                                          kernel = "linear",
                                          kparam = NULL,
                                          lambdas = 0.1,
                                          cvFolds = 0L,
                                          suppress = TRUE)

is(obj)
cvInfo(obj)
optimObj(obj)
DynTxRegime:::.predictOptimalTx(obj)
DynTxRegime:::.predictOptimalTx(obj,bmiData)
print(obj)
regimeCoef(obj)
show(obj)
summary(obj)

# }