GenStatR:
Generation of differential expression statistics
Description
Given a gene expression data matrix annotated to entrez gene IDs and a
phenotype vector, it will generate statistics of differential expression
using limma, at the gene-level, for all pairwise comparisons of phenotype levels.
Usage
GenStatR(exp.m,pheno.v)
Arguments
exp.m
The gene expression data matrix with rownames annotated to entrez gene
IDs. If there are multiple rows with the same gene ID, function will
average these.
pheno.v
The phenotype vector.
Value
top
A list of matrices, from the limma output, ranking genes
according to differential expression between two phenotypes as
specified in the contrasts matrix, i.e. top[[i]] will contain the
ranking for the i'th contrast.
cont
The contrasts matrix, with columns labeling the contrasts.
avexp
The averaged expression matrix at the gene-level.
Details
References
A systems-level integrative framework for genome-wide DNA methylation and gene expression data identifies differential gene expression modules under epigenetic control. Jiao Y, Widschwendter M, Teschendorff AE. Bioinformatics. 2014;30(16):2360-2366