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GESE (version 2.0.0)

Gene-Based Segregation Test

Description

Implements the gene-based segregation test(GESE) and the weighted GESE test for identifying genes with causal variants of large effects for family-based sequencing data. The methods are described in Qiao, D. Lange, C., Laird, N.M., Won, S., Hobbs, B., et al. 2016. Gene-based segregation method for identifying rare variants for family-based sequencing studies. More details can be found at .

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Version

Install

install.packages('GESE')

Monthly Downloads

497

Version

2.0.0

License

GPL-2

Maintainer

Last Published

November 16th, 2016

Functions in GESE (2.0.0)

GESE-package

\Sexpr[results=rd,stage=build]{tools:::Rd_package_title("#1")}GESEGene-Based Segregation Test
dataRaw

dataRaw - a data frame containing the pedigree, phenotype and genotype information
GESE-internal

GESE package internal functions
pednew

pednew - an example pedigree structure
trim_unrelated

Trims the pedigree structure to exclude multiple founder cases
mapInfo

mafInfo - example data
condSegProbF

Computes conditional segregation probability for the family
database

database file in example