Results of a clinical trial to compare two competing oral antifungal treatments for toenail infection.
data("toenail")A data frame with 1908 observations on the following 5 variables.
patientIDa unique identifier for each patient in the trial.
outcomedegree of separation of the nail plate from the nail bed (onycholysis).
treatmenta factor with levels itraconazole and terbinafine.
timethe time in month when the visit actually took place.
visitnumber of visit attended.
De Backer et al. (1998) describe a clinical trial to compare two competing oral antifungal
treatments for toenail infection (dermatophyte onychomycosis). A total of 378 patients
were randomly allocated into two treatment groups, one group receiving 250mg per
day of terbinafine and the other group 200mg per day of itraconazole.
Patients were evaluated at seven visits, intended to be at weeks
0, 4, 8, 12, 24, 36, and 48 for the degree of separation of the nail
plate from the nail bed (onycholysis) dichotomized into moderate or severe
and none or mild. But patients did not always arrive exactly at the
scheduled time and the exact time in months that they did attend was recorded.
The data is not balanced since not all patients attended for all seven planned
visits.
data("toenail", package = "HSAUR3")
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