genDataLoad

This function loads the data from the saved .ffData and .RData files,
and prepares the data to subsequent analysis.

Performs genetic association analyses of case-parent triad (trio) data with multiple markers. It can also incorporate complete or incomplete control triads, for instance independent control children. Estimation is based on haplotypes, for instance SNP haplotypes, even though phase is not known from the genetic data. 'Haplin' estimates relative risk (RR + conf.int.) and p-value associated with each haplotype. It uses maximum likelihood estimation to make optimal use of data from triads with missing genotypic data, for instance if some SNPs has not been typed for some individuals. 'Haplin' also allows estimation of effects of maternal haplotypes and parent-of-origin effects, particularly appropriate in perinatal epidemiology. 'Haplin' allows special models, like X-inactivation, to be fitted on the X-chromosome. A GxE analysis allows testing interactions between environment and all estimated genetic effects. The models were originally described in "Gjessing HK and Lie RT. Case-parent triads: Estimating single- and double-dose effects of fetal and maternal disease gene haplotypes. Annals of Human Genetics (2006) 70, pp. 382-396".

Hakon Gjessing

Haplin

Analyzing Case-Parent Triad and/or Case-Control Data with SNP
Haplotypes

Hakon K. Gjessing

Miriam Gjerdevik

Julia Romanowska

Oivind Skare

genDataLoad function

<dl><dt>filename</dt>
<dd>The base of the filenames; i.e. if the data is saved in
"my_data_gen.ffData", "my_data_gen.RData" and "my_data_cov.RData", then the 'filename'
should be "my_data".</dd>
<dt>dir.in</dt>
<dd>The path to the directory where files were saved (defaults to the
current directory).</dd></dl>

Arguments

Loading the data previously read in and saved by "genDataRead" — genDataLoad

<dl>

<dt>filename</dt>
<dd>The base of the filenames; i.e. if the data is saved in
"my_data_gen.ffData", "my_data_gen.RData" and "my_data_cov.RData", then the 'filename'
should be "my_data".</dd>


<dt>dir.in</dt>
<dd>The path to the directory where files were saved (defaults to the
current directory).</dd>

</dl>

genDataLoad: Loading the data previously read in and saved by "genDataRead"

Description

Usage

Value

Arguments