A randomized clinical trial in which both longitudinal and survival data were collected to compare the efficacy and safety of two antiretroviral drugs in treating patients who had failed or were intolerant of zidovudine (AZT) therapy.
A data frame with 1408 observations on the following 9 variables.
patient
patients identifier; in total there are 467 patients.
Time
the time to death or censoring.
death
a numeric vector with 0 denoting censoring and 1 death.
CD4
the CD4 cells count.
obstime
the time points at which the CD4 cells count was recorded.
drug
a factor with levels ddC
denoting zalcitabine and ddI
denoting didanosine.
gender
a factor with levels female
and male
.
prevOI
a factor with levels AIDS
denoting previous opportunistic infection (AIDS
diagnosis) at study entry, and noAIDS
denoting no previous infection.
AZT
a factor with levels intolerance
and failure
denoting AZT intolerance and
AZT failure, respectively.
Goldman, A., Carlin, B., Crane, L., Launer, C., Korvick, J., Deyton, L. and Abrams, D. (1996) Response of CD4+ and clinical consequences to treatment using ddI or ddC in patients with advanced HIV infection. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 11, 161--169.
Guo, X. and Carlin, B. (2004) Separate and joint modeling of longitudinal and event time data using standard computer packages. The American Statistician 58, 16--24.