het.weight

Internal function for calculating heterogeneity-penalized weights.

internal

Encodes several methods for performing Mendelian randomization
analyses with summarized data. Summarized data on genetic associations with the
exposure and with the outcome can be obtained from large consortia. These data
can be used for obtaining causal estimates using instrumental variable methods.

Stephen Burgess

MendelianRandomization

Mendelian Randomization Package

Olena Yavorska

James Staley

Fernando Hartwig

Jim Broadbent

Christopher Foley

Andrew Grant

Amy Mason

Ting Ye

Haoran Xue

Zhaotong Lin

Siqi Xu

Ashish Patel

Hyunseung Kang

Sheng Wang

Ville Karhunen

het.weight function

<dl><dt>prob.valid.inst</dt>
<dd>Probability (prior) of a genetic variant being a valid instrument.</dd>
<dt>bx</dt>
<dd>Genetic associations with risk factor.</dd>
<dt>by</dt>
<dd>Genetic associations with outcome.</dd>
<dt>byse</dt>
<dd>Standard errors of genetic associations with outcome.</dd></dl>

Arguments

Heterogeneity-penalized weight function — het.weight

<dl>

<dt>prob.valid.inst</dt>
<dd>Probability (prior) of a genetic variant being a valid instrument.</dd>


<dt>bx</dt>
<dd>Genetic associations with risk factor.</dd>


<dt>by</dt>
<dd>Genetic associations with outcome.</dd>


<dt>byse</dt>
<dd>Standard errors of genetic associations with outcome.</dd>

</dl>

Heterogeneity-penalized weight function

het.weight: Heterogeneity-penalized weight function

Description

Usage

Value

Arguments

Details

Examples