r.weights.delta

Internal function for calculating penalized weights in conjunction with <code>penalised.weights</code> with <code>weights</code> equal to <code>"delta"</code>.
These weights are used in either the <code>mr_ivw</code> or <code>mr_egger</code> functions when <code>penalized = TRUE</code>.

internal

Encodes several methods for performing Mendelian randomization
analyses with summarized data. Summarized data on genetic associations with the
exposure and with the outcome can be obtained from large consortia. These data
can be used for obtaining causal estimates using instrumental variable methods.

Stephen Burgess

MendelianRandomization

Mendelian Randomization Package

Olena Yavorska

James Staley

Fernando Hartwig

Jim Broadbent

Christopher Foley

Andrew Grant

Amy Mason

Ting Ye

Haoran Xue

Zhaotong Lin

Siqi Xu

Ashish Patel

Hyunseung Kang

Sheng Wang

Ville Karhunen

r.weights.delta function

<dl><dt>.Bx</dt>
<dd>Beta-coefficient for genetic association with the risk factor.</dd>
<dt>.Bxse</dt>
<dd>Standard error of genetic association with the risk factor.</dd>
<dt>.By</dt>
<dd>Beta-coefficient for genetic association with the outcome.</dd>
<dt>.Byse</dt>
<dd>Standard error of genetic association with the outcome.</dd>
<dt>.psi</dt>
<dd>The correlation between the genetic associations with the exposure and the association with the outcome for each variant resulting from sample overlap.</dd>
<dt>.pen.weights</dt>
<dd>Factors for penalizing weights.</dd></dl>

Arguments

Calculates p-values for penalization of weights with second-order weights — r.weights.delta

<dl>

<dt>.Bx</dt>
<dd>Beta-coefficient for genetic association with the risk factor.</dd>


<dt>.Bxse</dt>
<dd>Standard error of genetic association with the risk factor.</dd>


<dt>.By</dt>
<dd>Beta-coefficient for genetic association with the outcome.</dd>


<dt>.Byse</dt>
<dd>Standard error of genetic association with the outcome.</dd>


<dt>.psi</dt>
<dd>The correlation between the genetic associations with the exposure and the association with the outcome for each variant resulting from sample overlap.</dd>


<dt>.pen.weights</dt>
<dd>Factors for penalizing weights.</dd>

</dl>

Calculates p-values for penalization of weights with second-order weights

r.weights.delta: Calculates p-values for penalization of weights with second-order weights

Description

Usage

Value

Arguments

Details

Examples