weighted.median.boot.se

Internal function for calculating standard error of weighted median estimate (or simple median estimator if weights are all equal) using bootstrapping. The number of iterations and initial value of the random seed can also be set.

internal

Encodes several methods for performing Mendelian randomization
analyses with summarized data. Summarized data on genetic associations with the
exposure and with the outcome can be obtained from large consortia. These data
can be used for obtaining causal estimates using instrumental variable methods.

Stephen Burgess

MendelianRandomization

Mendelian Randomization Package

Olena Yavorska

James Staley

Fernando Hartwig

Jim Broadbent

Christopher Foley

Andrew Grant

Amy Mason

Ting Ye

Haoran Xue

Zhaotong Lin

Siqi Xu

Ashish Patel

Hyunseung Kang

Sheng Wang

Ville Karhunen

weighted.median.boot.se function

<dl><dt>Bx</dt>
<dd>A numeric vector of beta-coefficient values for genetic associations with the exposure.</dd>
<dt>By</dt>
<dd>A numeric vector of beta-coefficient values for genetic associations with the outcome.</dd>
<dt>Bxse</dt>
<dd>The standard errors associated with the beta-coefficients in <code>Bx</code>.</dd>
<dt>Byse</dt>
<dd>The standard errors associated with the beta-coefficients in <code>By</code>.</dd>
<dt>weights</dt>
<dd>Weights.</dd>
<dt>iter</dt>
<dd>The number of bootstrap samples to generate when calculating the standard error.</dd>
<dt>seed</dt>
<dd>The random seed to use when generating the bootstrap samples (for reproducibility). If set to <code>NA</code>, the random seed will not be set (for example, if the function is used as part of a larger simulation).</dd></dl>

Arguments

Weighted median standard error function — weighted.median.boot.se

<dl>

<dt>Bx</dt>
<dd>A numeric vector of beta-coefficient values for genetic associations with the exposure.</dd>


<dt>By</dt>
<dd>A numeric vector of beta-coefficient values for genetic associations with the outcome.</dd>


<dt>Bxse</dt>
<dd>The standard errors associated with the beta-coefficients in <code>Bx</code>.</dd>


<dt>Byse</dt>
<dd>The standard errors associated with the beta-coefficients in <code>By</code>.</dd>


<dt>weights</dt>
<dd>Weights.</dd>


<dt>iter</dt>
<dd>The number of bootstrap samples to generate when calculating the standard error.</dd>


<dt>seed</dt>
<dd>The random seed to use when generating the bootstrap samples (for reproducibility). If set to <code>NA</code>, the random seed will not be set (for example, if the function is used as part of a larger simulation).</dd>

</dl>

Weighted median standard error function

weighted.median.boot.se: Weighted median standard error function

Description

Usage

Value

Arguments

Details

Examples