plot,fcv,missing-method

Plot type. 1 is the distribution of the inner cross validated
HR under test data for each outer iterations and estimated HR on the out
of bag data are superimposed. 2 Estimated HR Density for low Risk Group.

type

The usual extra arguments to generic functions &lt;U+2014&gt; see
<code><a rd-options="graphics" href="/link/plot.default?package=MetabolicSurv&version=1.1.2&to=graphics" data-mini-rdoc="graphics::plot.default">plot.default</a></code>

An approach to identifies metabolic biomarker signature for metabolic data by discovering predictive metabolite for predicting survival and classifying patients into risk groups.
Classifiers are constructed as a linear combination of predictive/important metabolites, prognostic factors and treatment effects if necessary.
Several methods were implemented to reduce the metabolomics matrix such as the principle component analysis of Wold Svante et al. (1987) <doi:10.1016/0169-7439(87)80084-9> ,
the LASSO method by Robert Tibshirani (1998) <doi:10.1002/(SICI)1097-0258(19970228)16:4%3C385::AID-SIM380%3E3.0.CO;2-3>, the
elastic net approach by Hui Zou and Trevor Hastie (2005) <doi:10.1111/j.1467-9868.2005.00503.x>.
Sensitivity analysis on the quantile used for the classification can also be accessed to check the deviation of the classification group based on the quantile specified.
Large scale cross validation can be performed in order to investigate the mostly selected predictive metabolites and for internal validation. During the evaluation process, validation is accessed using the hazard ratios (HR) distribution of the test set and inference is mainly based on resampling and permutations technique.

Olajumoke Evangelina Owokotomo

MetabolicSurv

A Biomarker Validation Approach for Classification and
Predicting Survival Using Metabolomics Signature

Ziv Shkedy

plot,fcv,missing-method function

The usual extra arguments to generic functions &lt;U+2014&gt; see
<code><a rd-options='graphics' href='plot.default'>plot.default</a></code>

plot,fcv,missing-method: Plot method for fcv class

Description

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