comp.CVD_score

Function to compute CVD-score made by Peter Wurtz et al. made by Deelen et al. on Nightingale metabolomics data-set.

Provides an intuitive framework for ad-hoc statistical analysis of 1H-NMR metabolomics by Nightingale Health. It allows to easily explore new metabolomics measurements assayed by Nightingale Health, comparing the distributions with a large Consortium (BBMRI-nl); project previously published metabolic scores [<doi:10.1016/j.ebiom.2021.103764>, <doi:10.1161/CIRCGEN.119.002610>, <doi:10.1038/s41467-019-11311-9>, <doi:10.7554/eLife.63033>, <doi:10.1161/CIRCULATIONAHA.114.013116>, <doi:10.1007/s00125-019-05001-w>]; and calibrate the metabolic surrogate values to a desired dataset.

Daniele Bizzarri

MiMIR

Metabolomics-Based Models for Imputing Risk

Marcel Reinders

Marian Beekman

Pieternella Eline Slagboom

Erik van den Akker

comp.CVD_score function

<dl><dt>met</dt>
<dd>numeric data-frame with Nightingale-metabolomics</dd>
<dt>phen</dt>
<dd>data-frame containing phenotypic information of the samples (specifically: sex, systolic_blood_pressure, current_smoking, diabetes, blood_pressure_lowering_med, lipidmed, totchol, and hdlchol)</dd>
<dt>betas</dt>
<dd>The betas of the linear regression composing the CVD-score</dd>
<dt>quiet</dt>
<dd>logical to suppress the messages in the console</dd></dl>

Arguments

comp.CVD_score — comp.CVD_score

<dl>

<dt>met</dt>
<dd>numeric data-frame with Nightingale-metabolomics</dd>


<dt>phen</dt>
<dd>data-frame containing phenotypic information of the samples (specifically: sex, systolic_blood_pressure, current_smoking, diabetes, blood_pressure_lowering_med, lipidmed, totchol, and hdlchol)</dd>


<dt>betas</dt>
<dd>The betas of the linear regression composing the CVD-score</dd>


<dt>quiet</dt>
<dd>logical to suppress the messages in the console</dd>

</dl>

comp.CVD_score: comp.CVD_score

Description

Usage

Value

Arguments

References

See Also

Examples