MiST-package: Mixed effects Score Test

Description

Test for association between a set of SNPS/genes and continuous or binary outcomes by including variant characteristic information and using score statistics.

Arguments

Details

Package:

MiST

Type:

Package

Version:

1.0

Date:

2013-03-18

License:

LGPL (>= 2.0)

LazyLoad:

yes

linear.test(y, X, G, Z, method = "liu")

linear.weight.test(y, X, G, Z, maf, weight.beta = c(1, 25), method = "liu")

logit.test(y, X, G, Z, method = "liu")

logit.weight.test(y, X, G, Z, maf, weight.beta = c(1, 25), method = "liu")

References

Sun, J., Zheng, Y., and Hsu, L. (2013) A Unified Mixed-Effects Model for Rare-Variant Association in Sequencing Studies. Genet Epidemiol. 2013 Mar 9. doi: 10.1002/gepi.21717 H. Liu, Y. Tang, H.H. Zhang (2009) A new chi-square approximation to the distribution of non-negative definite quadratic forms in non-central normal variables, Computational Statistics and Data Analysis, 53, 853-856.