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It calculates AUC and AUMC using the linear trapezoidal method
LinAUC(x, y)
area under the curve
area under the first moment curve
vector values of the independent variable, usually time
vector values of the dependent variable, usually concentration
Kyun-Seop Bae <k@acr.kr>
This function returns AUC and AUMC by the linear trapezoidal method.
Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016.
Shargel L, Yu A. Applied Biopharmaceutics and Pharmacokinetics. 7th ed. 2015.
Rowland M, Tozer TN. Clinical Pharmacokinetics and Pharmacodynamics - Concepts and Applications. 4th ed. 2011.
Gibaldi M, Perrier D. Pharmacokinetics. 2nd ed. revised and expanded. 1982.
LogAUC, AUC
LogAUC
AUC
LinAUC(Theoph[Theoph$Subject==1, "Time"], Theoph[Theoph$Subject==1, "conc"]) AUC(Theoph[Theoph$Subject==1, "Time"], Theoph[Theoph$Subject==1, "conc"]) # compare the last line
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