NonCompart (version 0.7.0)

gAUC: General Area Under the Curve

Description

General AUC function for Emax, TEmax and AUCs

Usage

gAUC(x, y, Ymax = "Emax", XofYmax = "TEmax", AUCname = "AUEClast", iAUC = "", 
     Outer = "NEAREST")

Value

Column names can vary according to the options.

Emax

maximum y value

TEmax

x value at the maximum y value

AUEClast

Area under the y versus x curve

iAUCs

Columns from iAUC input

Arguments

x

usually time

y

usually concentration or effect. This can be negative/

Ymax

usually Cmax or Emax

XofYmax

usually Tmax or TEmax

AUCname

usually AUClast or AUEClast

iAUC

a data.frame to calculate interval AUCs

Outer

indicates how to do the out of x range point

Author

Kyun-Seop Bae <[e-mail]>

Details

This is a general purpose AUC function. It calculates only Cmax(Emax), Tmax(TEmax) and AUCs(AUECs). This can be used for effect(pharmacodynamic) data which has negative values. For concentration data, use IntAUC.

Examples

# For one subject
x = Theoph[Theoph$Subject=="1", "Time"]
y = Theoph[Theoph$Subject=="1", "conc"]
gAUC(x, y)

iAUC = data.frame(Name=c("AUC[0-12h]","AUC[0-24h]"), Start=c(0,0), End=c(12,24))
gAUC(x, y, iAUC=iAUC)