FM.chi.pvalue:
Calculates the Fisher's method p-value for each tested pathway
Description
Calculates the Fisher's method p-value for a set of p-values. It returns both the p-value and the test statistic value of the Fisher's product method.
Usage
FM.chi.pvalue(x)
Arguments
x
A vector of p-values. These p-values can be either gene or SNP p-values of a tested pathway
Value
FMstatistic
Fisher's product method test statistic
FMpvalue
Fisher's method p-value, computed using the exact distribution of the Fisher's method test statistic which is a Chi^2 distribution with degrees of freedom twice the size of vector x
References
Evangelou M, Rendon A, Ouwehand WH, Wernisch L, Dudbridge F (2012) Comparison of Methods for Competitive Tests of Pathway Analysis. PLoS ONE 7(7): e41018. doi:10.1371/journal.pone.0041018