PARSE (version 0.1.0)

response2drug: Gene-expression Data for Asthma Disease

Description

The data contains gene expression data of 108 objects.

Usage

data(response2drug)

Format

Rows

Objects

Columns

Genes

Source

http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE43696

Details

This is the microarray gene expression data from NCBI's Gene Expression Omnibus database with Gene Expression Omnibus Series accession number GSE43696. The data consist of 108 samples with 20 healthy, 50 moderate asthma and 38 severe asthma patients; and 405 genes. Each row represents one observation and each column represents one gene.

References

Voraphani, N., Gladwin, M.T., Contreras, A.U., Kaminski, N., Tedrow, J.R., Milosevic, J., Bleecker, E.R., Meyers, D.A., Ray, A., Ray, P. and Erzurum, S.C. (2014) An airway epithelial iNOS-DUOX2-thyroid peroxidase metabolome drives Th1/Th2 nitrative stress in human severe asthma. Mucosal immunology 7(5), 1175-1185.

Examples

data(response2drug)
output1 = parse (K=2, lambda = 1, y = response2drug, N = 100,
kms.iter = 50, kms.nstart = 50, eps.diff = 1e-5, eps.em = 1e-5,
model.crit = 'gic', backward = TRUE, cores = 2)
output1$mu.hat.best[, 1:5]