Learn R Programming

PSCBS (version 0.67.0)

callCopyNeutralByTCNofAB.PairedPSCBS: Calls regions that are copy neutral

Description

Calls regions that are copy neutral from the total copy numbers (TCNs) of segments in allelic balance (AB).

Usage

# S3 method for PairedPSCBS
callCopyNeutralByTCNofAB(fit, delta=estimateDeltaCN(fit), alpha=0.05, ..., force=FALSE,
  verbose=FALSE)

Value

Returns a PairedPSCBS fit object where a column with the copy-neutral call.

Arguments

fit

A PairedPSCBS fit object as returned by segmentByPairedPSCBS.

delta

A non-negative double specifying the width of the "acceptance" region. Defaults to half of the distance between two integer TCN states, i.e. 1/2. This argument should be shrunken as a function of the amount of the normal contamination and other background signals.

alpha

A double in [0,0.5] specifying the significance level of the confidence intervals used.

...

Additional arguments passed to *calcStatsForCopyNeutralABs().

force

If TRUE, an already called object is skipped, otherwise not.

verbose

See Verbose.

Author

Henrik Bengtsson

Details

...