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Phase123 (version 2.1)

Simulating and Conducting Phase 123 Trials

Description

Contains three simulation functions for implementing the entire Phase 123 trial and the separate Eff-Tox and Phase 3 portions of the trial, which may be beneficial for use on clusters. The functions AssignEffTox() and RandomizeEffTox() assign doses to patient cohorts during phase 12 and Reoptimize() determines the optimal dose to continue with during Phase 3. The functions ReturnMeansAgent() and ReturnMeanControl() gives the true mean survival for the agent doses and control and ReturnOCS() gives the operating characteristics of the design.

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Version

Install

install.packages('Phase123')

Monthly Downloads

175

Version

2.1

License

GPL-2

Maintainer

Andrew Chapple

Last Published

April 25th, 2019

Functions in Phase123 (2.1)

PieceMCMC

Returns posterior distribution for key mixture model parameters
AssignEffTox

Determines the optimal dose to assign the next patient cohort.
ReturnMeansAgent

Gives true mean survival times for doses considered of the experimental agent.
RandomEffTox

Randomizes Eff-Tox dose proportional to posterior desireability scores.
EFFTOX

Obtains estimated posterior probabilities of the four outcomes of (YE,YT) for each dose.
ReturnOCS

Gives operating characteristics of phase 123 and conventional design.
RunAdaptiveEffToxTrial

Simulates repitions of an Adaptive Eff-Tox Trial.
SimPhase123

Simulates replications of the phase123 and phase 12-3 trials.
ReturnMeanControl

Gives true mean survival times for the control therapy.
SimPhase3

Performs one replication of phase 3 for the phase 123 design, given phase 12 data.
Reoptimize1

Gives the Optimal Dose for enrolling next patient cohort. Used in the SimPhase123 function.
Reoptimize

Gives the Optimal Dose for enrolling next patient cohort.