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PowerTOST (version 1.5-6)

ct9.6.2+ct9.6.6: Sample Size Tables for the 2x2x3 Replicate Crossover Design

Description

These data.frames give sample size tables calculated with sampleN.TOST() for the 2×2×3 replicate crossover design (2-treatment 2-sequence 3-period design.

Arguments

Author

PowerTOST

Details

The data.frames can be accessed by their names.

data.frameDescription
ct9.6.2Additive model, theta1=--0.2, theta2=+0.2 (BE limits 0.80 -- 1.20)
approximate power via shifted non-central t-distribution
ct9.6.6Multiplicative model, theta1=0.8, theta2=1.25 (1/theta1)
approximate power via shifted non-central t-distribution

Attention! CV is se (standard error) of residuals.

References

Chow SC, Liu JP. Design and Analysis of Bioavailability and Bioequivalence Studies. Boca Raton: CRC Press; 3rd edition 2009.

Examples

Run this code
ct9.6.2
ct9.6.6

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