FitOLS

Inverse normal transformation (INT) based genetic association testing. These tests are recommend for continuous traits with non-normally distributed residuals. INT-based tests robustly control the type I error in settings where standard linear regression does not, as when the residual distribution exhibits excess skew or kurtosis. Moreover, INT-based tests outperform standard linear regression in terms of power. These tests may be classified into two types. In direct INT (D-INT), the phenotype is itself transformed. In indirect INT (I-INT), phenotypic residuals are transformed. The omnibus test (O-INT) adaptively combines D-INT and I-INT into a single robust and statistically powerful approach. See McCaw ZR, Lane JM, Saxena R, Redline S, Lin X. "Operating characteristics of the rank-based inverse normal transformation for quantitative trait analysis in genome-wide association studies" <doi:10.1111/biom.13214>.

Zachary McCaw

RNOmni

Rank Normal Transformation Omnibus Test

FitOLS function

<dl><dt>y</dt>
<dd>Nx1 Numeric vector.</dd>
<dt>X</dt>
<dd>NxP Numeric matrix.</dd></dl>

Arguments

Ordinary Least Squares — FitOLS

<dl>

<dt>y</dt>
<dd>Nx1 Numeric vector.</dd>


<dt>X</dt>
<dd>NxP Numeric matrix.</dd>

</dl>

FitOLS: Ordinary Least Squares

Description

Usage

Value

Arguments