RRate (version 1.0)

SEest: Estimating standard error of the observed log-odds ratio

Description

SEest implements the Woolf's method to estimate the standard error of the observed log-odds ratio.

Usage

SEest(n0,n1,fU,fA)

Arguments

n0

Sample size in the control group.

n1

Sample size in the case group.

fU

Allele frequency in the control group.

fA

Allele frequency in the case group.

Value

The estimated standard error is returned.

Details

The Woolf's method to estimate the standard error of log(OR) is based on the following formula:

se(log(OR))=sqrt(1/(n0 fU(1-fU))+1/(n1 fA(1-fA))).

References

Woolf, B. (1955). On estimating the relation between blood group and disease. Ann Hum Genet, 19(4), 251-253.

Jiang, W., Xue, J-H, and Yu, W. What is the probability of replicating a statistically significant association in genome-wide association studies?. Submitted.

See Also

RRate, repRateEst, repSampleSizeRR, repSampleSizeRR2, HLtest

Examples

##Load data
data('smryStats1')        #Example of summary statistics in 1st study
n2.0<-2000                #Number of individuals in control group
n2.1<-2000                #Number of individuals in case group

SE2<-SEest(n2.0, n2.1, smryStats1$F_U, smryStats1$F_A) #SE in replication study