Y.HNSCC.averageBetas

<p>Peripheral blood from 92 head and neck squamous cell carcinoma (HNSCC) patients and 92 controls. 
GEO Accession #GSE32393 with 2 outlier cases removed.</p>


Reference-free method for conducting EWAS while deconvoluting DNA methylation
arising as mixtures of cell types.  The older method
(Houseman et al., 2014,<doi:10.1093/bioinformatics/btu029>) is similar to
surrogate variable analysis (SVA and ISVA), except that it makes additional use
of a biological mixture assumption.
The newer method (Houseman et al., 2016, <doi:10.1186/s12859-016-1140-4>) is similar
to non-negative matrix factorization, with additional constraints
and additional utilities.

E. Houseman

RefFreeEWAS

EWAS using Reference-Free DNA Methylation Mixture Deconvolution

Y.HNSCC.averageBetas function

<p>Numeric matrix of dimension 26486 by 182</p>

Y.HNSCC.averageBetas: HNSCC Example - DNA Methylation Average Betas

Description

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