rfEwasExampleBetaValues

<p>1000 CpG sites x 250 subjects.  First 250 CpGs are DMRs for the cell types, although the idea is that this would not be known in practice.</p>


Reference-free method for conducting EWAS while deconvoluting DNA methylation
arising as mixtures of cell types.  The older method
(Houseman et al., 2014,<doi:10.1093/bioinformatics/btu029>) is similar to
surrogate variable analysis (SVA and ISVA), except that it makes additional use
of a biological mixture assumption.
The newer method (Houseman et al., 2016, <doi:10.1186/s12859-016-1140-4>) is similar
to non-negative matrix factorization, with additional constraints
and additional utilities.

E. Houseman

RefFreeEWAS

rfEwasExampleBetaValues: Simulated mixed-cell DNA methylation data set

Description

Usage

Arguments

Format