tobit.test: Differential expression testing using Tobit models
Description
Identifies differentially expressed genes between two groups of cells using
Tobit models, as proposed in Trapnell et al., Nature Biotechnology, 2014
Usage
tobit.test(object, cells.1, cells.2, genes.use = NULL, thresh.use = log(2))
Arguments
genes.use
Genes to test. Default is to use all genes.
thresh.use
Limit testing to genes which show, on average, at least
X-fold difference (log-scale) between the two groups of cells.Increasing thresh.use speeds up the function, but can miss weaker signals.
Value
Returns a p-value ranked matrix of putative differentially expressed
genes.